Your browser doesn't support javascript.
loading
Adiposity and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study
Wang, Mengmeng; Zhang, Zhizhong; Daghlas, Iyas; Gill, Dipender; Liu, Dandan; Lian, Xuegan.
Affiliation
  • Wang M; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
  • Zhang Z; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
  • Daghlas I; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
  • Gill D; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
  • Liu D; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
  • Lian X; From the Department of Neurology (M.W., X.L.), The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Neurology (Z.Z.), Jinling Hospital, Medical School of Nanjing University, China; Department of Neurology (I.D.), University of California San Francisco; Department of E
Neurology ; 102(3): e208080, 2024 02 13.
Article in En | MEDLINE | ID: mdl-38181322
ABSTRACT
BACKGROUND AND

OBJECTIVES:

To investigate the causal relationships of abdominal adiposity (waist-to-hip ratio [WHR]) and overall adiposity (body mass index [BMI]) with functional outcome after ischemic stroke using Mendelian randomization.

METHODS:

Genetic instruments for WHR and BMI were obtained from the largest available genome-wide association studies meta-analysis of the Genetic Investigation of ANthropometric Traits consortium and the UK Biobank (N max = 806,834). Functional outcome after ischemic stroke was assessed using the modified Rankin Scale (mRS) score at 3-month after stroke onset, with mRS >2 (mRS 3-6) defined as an unfavorable functional outcome. Corresponding genetic estimates for an unfavorable functional outcome were extracted from the Genetics of Ischemic Stroke Functional Outcome network (N = 6,021). We applied a random-effects inverse variance weighted method as our main analysis.

RESULTS:

Genetically predicted higher WHR (per 0.09 ratio units) was associated with unfavorable functional outcome after ischemic stroke (mRS 3-6, OR = 1.48; 95% CI = 1.03-2.13; p = 0.033). The results remained directionally consistent in sensitivity analyses. Conversely, genetically predicted BMI (per 4.8 kg/m2) was not associated with unfavorable functional outcome after ischemic stroke (OR = 1.01; 95% CI = 0.75-1.36; p = 0.937).

DISCUSSION:

This study provides genetic evidence supporting the hypothesis that abdominal adiposity has a detrimental effect on functional recovery after ischemic stroke.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adiposity / Ischemic Stroke Type of study: Clinical_trials / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Neurology Year: 2024 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adiposity / Ischemic Stroke Type of study: Clinical_trials / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Neurology Year: 2024 Document type: Article Country of publication: Estados Unidos