[Retrospective analysis of venlafaxine-induced hypoglycemia in patients with overdose]. / Análisis retrospectivo de las hipoglucemias inducidas por venlafaxina en pacientes con sobredosis.
Med Clin (Barc)
; 162(7): 328-332, 2024 04 12.
Article
in En, Es
| MEDLINE
| ID: mdl-38182480
ABSTRACT
INTRODUCTION:
Recent publications relate the presence of hypoglycemia in venlafaxine (VLX) poisoning depending on the dose. Our aim was to analyze the clinical characteristics of patients who presented hypoglycemia induced by VLF overdose. PATIENTS ANDMETHODS:
Retrospective study carried out in the Balearic Islands (2020-2023). INCLUSION CRITERIA serum concentrations of VLX + O-desmethyl-venlafaxine (O-VLX)>800 ng/mL. The characteristics of patients with and without hypoglycemia were compared.RESULTS:
Twenty-one patients were included, 8 (38.1%) with hypoglycemia. No differences were found in the doses referred to in both groups. Peak concentrations of VLX + O-VLX (ng/mL) were 9,783 [4,459-17,976] in patients with hypoglycemia and 1,413 [930-1,719] in patients without hypoglycemia (p<0.0001). The presence of hypoglycemia was associated with lower age and level of consciousness; and higher frequency of suicide attempts, seizures, mydriasis, tachycardia and serotonin syndrome, invasive respiratory support, fluid therapy and ICU admission (p<0.05).CONCLUSIONS:
The detection of hypoglycemia in a VLX overdose case is a readily available marker to suspect the severity of the patient. In any case, serum concentrations when available allow us to confirm intoxication.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Overdose
/
Hypoglycemia
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
/
Es
Journal:
Med Clin (Barc)
Year:
2024
Document type:
Article