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C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018-2023).
Helal, Mohamed H; Owda, Medhat E; Mogharbel, Amal T; Hamzah Alessa, Ali; Omer, Noha; Abdelaziz, Mahmoud A; Ibrahim, Islam; Eliwa, Essam M.
Affiliation
  • Helal MH; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, 91911, PO 840, Saudi Arabia.
  • Owda ME; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt.
  • Mogharbel AT; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia.
  • Hamzah Alessa A; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia.
  • Omer N; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia.
  • Abdelaziz MA; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia.
  • Ibrahim I; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt; Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.
  • Eliwa EM; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt; Institute of Chemistry of Strasbourg, UMR 7177-LCSOM, CNRS, Strasbourg University, 4 Rue Blaise Pascal, 67000 Strasbourg, France. Electronic address: essameliwa85@azhar.edu.eg.
Bioorg Chem ; 143: 107091, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38183683
ABSTRACT
This scientific review documents the recent progress of C3-spirooxindoles chemistry (synthesis and reaction mechanism) and their bioactivities, focusing on the promising results as well as highlighting the biological mechanism via the reported molecular docking findings of the most bioactive derivatives. C3-Spirooxindoles are attractive bioactive agents and have been found in a variety of natural compounds, including alkaloids. They are widely investigated in the field of medicinal chemistry and play a key role in medication development, such as antivirals, anticancer agents, antimicrobials, etc. Regarding organic synthesis, several traditional and advanced strategies have been reported, particularly those that started with isatin derivatives.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Benzopyrans / Spirooxindoles / Nitriles Language: En Journal: Bioorg Chem / Bioorganic chem / Bioorganic chemistry Year: 2024 Document type: Article Affiliation country: Arabia Saudita Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Benzopyrans / Spirooxindoles / Nitriles Language: En Journal: Bioorg Chem / Bioorganic chem / Bioorganic chemistry Year: 2024 Document type: Article Affiliation country: Arabia Saudita Country of publication: Estados Unidos