Association between the remnant cholesterol to high-density lipoprotein cholesterol ratio and the risk of coronary artery disease.
Coron Artery Dis
; 35(2): 114-121, 2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38189652
ABSTRACT
BACKGROUND:
The purpose of this study was to evaluate the relationship between remnant cholesterol (RC) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also investigated the clinical value of RC/HDL-C ratio in evaluating the severity of CAD and in predicting the short-term prognosis of CAD patients.METHODS:
In total, 615 patients were enrolled and they were classified into a CAD group (418 cases) and a normal group (197 cases) according to the results of coronary angiography. Serum RC/HDL-C ratio and Gensini score were calculated. Multivariate logistic regression and receiver operating characteristic (ROC) curves were employed to evaluate the association between RC/HDL-C ratio and CAD. The effect of RC/HDL-C ratio on the progression of major adverse cardiovascular events (MACEs) was also explored.RESULTS:
Increased RC/HDL-C ratio was associated with an increased risk of CAD (OR 11.122; 95% CI 5.903-20.954; P â <â 0.001). When stratified by CAD subtypes, increased RC/HDL-C ratio was correlated with a greater risk of acute coronary syndrome (ACS) (OR1.549; 95% CI 1.014-2.364; P â <â 0.05). Compared with the first quartile, the 4th quartile of RC/HDL-C ratio had a 9.774-fold ( P â =â 0.000) increase in the odds ratio for CAD, and a 2.241-fold ( P â =â 0.017) increase in the odds ratio for ACS. RC/HDL-C ratio was an independent determinant of Gensini score ≥32 (OR 2.138, 95% CI1.389-3.292, P â <â 0.01), and multi-branch (MVD) (OR 2.245; 95% CI 1.468-3.443; P â <â 0.001). The prevalence of Gensini score ≥32 and MVD in the 4th quartile of RC/HDL-C ratio group were much higher than that of other quartile groups ( P â <â 0.01). Moreover, the areas under the ROC for the predictive value of RC/HDL-C ratio for CAD, ACS, Gensini score ≥32, and MVD were 0.702, 0.563, 0.602, and 0.669, respectively. Furthermore, the incidence of MACEs was significantly increased in CAD patients with levels of RC/HDL-C ratio ( P â <â 0.05).CONCLUSION:
RC/HDL-C ratio plays an important role in the progression and severity of CAD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Acute Coronary Syndrome
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Coron Artery Dis
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2024
Document type:
Article