Familial factors rather than paternal age contribute to the aetiology of epilepsy.
Int J Epidemiol
; 53(1)2024 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-38199793
ABSTRACT
BACKGROUND:
Whether paternal age associated with offspring's epilepsy risk is a cause of de novo mutation as men age, or just an association due to confounding factors, is still unclear.METHODS:
We performed a population-based, multi-generation and sibling comparison study in Taiwan, which included 2â751â232 singletons born in 2001-17 who were followed until 2020. Of these, 819â371/826â087 with information on paternal/maternal grandparents were selected for multi-generation analyses and 1â748â382 with sibling(s) were selected for sibling comparison. Cox proportional hazard regression was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).RESULTS:
In the total cohort, there was an increased risk of epilepsy in individuals with advanced paternal age, e.g. the HR for paternal age ≥50 was1.36 (95% CI 1.15-1.61) compared with paternal age 25-29, and fathers older than mothers, e.g. the HR for parental age difference ≥15 years was 1.29 (95% CI 1.16-1.43). When accounting for parental age difference, the association between paternal age and epilepsy in offspring was attenuated (HR for paternal age ≥50 was 1.11, 95% CI 0.93-1.34). Multi-generation analyses did not support the association of advanced grand-paternal age at childbirth of the parent with offspring's risk of epilepsy. Sibling comparison analyses did not support the association of older paternal age with increased risk of epilepsy (HR was 0.96 for per year increase in paternal age, 95% CI 0.96-0.97).CONCLUSIONS:
These results do not support the hypothesis that advanced paternal age is associated with epilepsy in offspring. Instead, familial factors may explain the observed paternal age association with the offspring's risk of epilepsy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paternal Age
/
Epilepsy
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Int J Epidemiol
Year:
2024
Document type:
Article
Affiliation country:
Taiwán