Epidemiology and microbiology of recurrent UTI in women in the community in Oxfordshire, UK.
JAC Antimicrob Resist
; 6(1): dlad156, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38204597
ABSTRACT
Background:
Recurrent urinary tract infection (rUTI) contributes to significant morbidity and antibiotic usage.Objectives:
To characterize the age of women experiencing rUTI, the microbiology of rUTIs, and the risk of further rUTIs in Oxfordshire, UK. Patients andmethods:
We retrospectively analysed de-identified linked microbiology and hospital admissions data (Infections in Oxfordshire Research Database), between 2008 and 2019, including positive urine cultures from women aged ≥16â years in community settings. We defined rUTI as ≥2 positive urine cultures within 6â months or ≥3 within 12â months.Results:
Of 201â927 women with urine culture performed, 84â809 (42%) had ≥1 positive culture, and 15â617 (18%) of these experienced ≥1 rUTI over a median (IQR) follow-up of 6 (3-9)â years. Women with rUTI were 17.0 (95% CI 16.3-17.7)â years older on average. rUTI was commonest (6204; 40%) in those aged 70-89â years. Post-rUTI, the risk of further UTI within 6â months was 29.4% (95% CI 28.7-30.2). Escherichia coli was detected in 65% of positive cultures. Among rUTIs where the index UTI was E. coli associated, the second UTI was also E. coli associated in 81% of cases.Conclusions:
rUTIs represent a substantial healthcare burden, particularly in women >60â years. One-third of women experiencing rUTI have a further microbiologically confirmed UTI within 6â months.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Screening_studies
Language:
En
Journal:
JAC Antimicrob Resist
Year:
2024
Document type:
Article
Affiliation country:
Reino Unido