Abnormal motor cortical plasticity as a useful neurophysiological biomarker for Alzheimer's disease pathology.
Clin Neurophysiol
; 158: 170-179, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38219406
ABSTRACT
OBJECTIVE:
Amyloid-beta (Aß) and tau accumulations impair long-term potentiation (LTP) induction in animal hippocampi. We investigated relationships between motor-cortical plasticity and biomarkers for Alzheimer's disease (AD) diagnosis in subjects with cognitive decline.METHODS:
Twenty-six consecutive subjects who complained of memory problems participated in this study. We applied transcranial quadripuse stimulation with an interstimulus interval of 5 ms (QPS5) to induce LTP-like plasticity. Motor-evoked potentials were recorded from the right first-dorsal interosseous muscle before and after QPS5. Cognitive functions, Aß42 and tau levels in the cerebrospinal fluid (CSF) were measured. Amyloid positron-emission tomography (PET) with11C-Pittsburg compound-B was also conducted. We studied correlations of QPS5-induced plasticity with cognitive functions or AD-related biomarkers.RESULTS:
QPS5-induced LTP-like plasticity positively correlated with cognitive scores. The degree of LTP-like plasticity negatively correlated with levels of CSF-tau, and the amount of amyloid-PET accumulation at the precuneus, and correlated with the CSF-Aß42 level positively. In the amyloid-PET positive subjects, non-responder rate of QPS5 was higher than the CSF-tau positive rate.CONCLUSIONS:
Findings suggest that QPS5-induced LTP-like plasticity is a functional biomarker of AD. QPS5 could detect abnormality at earlier stages than CSF-tau in the amyloid-PET positive subjects.SIGNIFICANCE:
Assessing motor-cortical plasticity could be a useful neurophysiological biomarker for AD pathology.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alzheimer Disease
/
Cognitive Dysfunction
Limits:
Humans
Language:
En
Journal:
Clin Neurophysiol
/
Clin. neurophysiol
/
Clinical neurophysiology
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Países Bajos