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Hedscandines A-C, three undescribed indole alkaloids from Hedyotis scandens with their anti-MRSA activity.
Wang, Yu-Jun; Chen, Xue; Yin, Yong; Zhou, Wei; Zhou, Pei-Fu; Zeng, Ling-Gao; Hu, Chang-Hua; Yin, Guo-Ping.
Affiliation
  • Wang YJ; Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China.
  • Chen X; Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China.
  • Yin Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.
  • Zhou W; Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China.
  • Zhou PF; Key Laboratory of Guizhou Ethnic Medicine Resource Development and Utilization, State Ethnic Affairs Commission, School of Chinese Ethnic Medicine, Guizhou Minzu University, Guiyang, Guizhou, 550025, China.
  • Zeng LG; NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing Institute for Food and Drug Control, Chongqing, 401121, China.
  • Hu CH; Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China. Electronic address: chhhu@swu.edu.cn.
  • Yin GP; Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China. Elec
Phytochemistry ; 219: 113988, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38224846
ABSTRACT
Hedscandines A-C (1-3), three undescribed indole alkaloids were isolated from Hedyotis scandens Roxb, a traditional Chinese medicine widely used in the treatment of respiratory ailments. Their structures were elucidated by extensive spectroscopic data and electronic circular dichroism calculation. Hedscandine A (1), possessed a unique carbon skeleton with a 1,4-oxazonin-2(3H)-one core system and displayed a rapid bactericidal activity against MRSA with a MIC value of 16 µg/mL. Mechanistic studies showed that compound 1 could disrupt the integrity of bacterial cell membranes and thus lead to bacterial death.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hedyotis / Methicillin-Resistant Staphylococcus aureus Language: En Journal: Phytochemistry Year: 2024 Document type: Article Affiliation country: China Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hedyotis / Methicillin-Resistant Staphylococcus aureus Language: En Journal: Phytochemistry Year: 2024 Document type: Article Affiliation country: China Country of publication: Reino Unido