Doxapram for apnoea of prematurity and neurodevelopmental outcomes at age 5-6 years.
Arch Dis Child Fetal Neonatal Ed
; 109(4): 443-449, 2024 Jun 19.
Article
in En
| MEDLINE
| ID: mdl-38228381
ABSTRACT
OBJECTIVE:
To assess the long-term neurodevelopmental impact of doxapram for treating apnoea of prematurity.DESIGN:
Secondary analysis of the French national cohort study EPIPAGE-2. Recruitment took place in 2011. A standardised neurodevelopmental assessment was performed at age 5-6 years. A 21 propensity score matching was used to control for the non-randomised assignment of doxapram treatment.SETTING:
Population-based cohort study. PATIENTS All children born before 32 weeks' gestation alive at age 5-6 years.INTERVENTIONS:
Blind and standardised assessment by trained neuropsychologists and paediatricians at age 5-6 years. MAIN OUTCOMEMEASURES:
Neurodevelopmental outcomes at age 5-6 years assessed by trained paediatricians and neuropsychologists cerebral palsy, developmental coordination disorders, IQ and behavioural difficulties. A composite criterion for overall neurodevelopmental disabilities was built.RESULTS:
The population consisted of 2950 children; 275 (8.6%) received doxapram. Median (IQR) gestational age was 29.4 (27.6-30.9) weeks. At age 5-6 years, complete neurodevelopmental assessment was available for 60.3% (1780 of 2950) of children and partial assessment for 10.6% (314 of 2950). In the initial sample, children receiving doxapram had evidence of greater clinical severity than those not treated. Doxapram treatment was associated with overall neurodevelopmental disabilities of any severity (OR 1.43, 95% CI 1.07 to 1.92, p=0.02). Eight hundred and twenty-one children were included in the 21 matched sample. In this sample, perinatal characteristics of both groups were similar and doxapram treatment was not associated with overall neurodevelopmental disabilities (OR 1.09, 95% CI 0.76 to 1.57, p=0.63).CONCLUSIONS:
In children born before 32 weeks' gestation, doxapram treatment for apnoea of prematurity was not associated with neurodevelopmental disabilities.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apnea
/
Infant, Premature
/
Doxapram
/
Neurodevelopmental Disorders
/
Infant, Premature, Diseases
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Newborn
Country/Region as subject:
Europa
Language:
En
Journal:
Arch Dis Child Fetal Neonatal Ed
Journal subject:
PEDIATRIA
/
PERINATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Francia
Country of publication:
Reino Unido