Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy.
Cancer Res
; 84(6): 800-807, 2024 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-38231470
ABSTRACT
Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1-mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Programmed Cell Death 1 Receptor
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer Res
Year:
2024
Document type:
Article
Affiliation country:
Taiwán