Vitamin D deficiency promotes intracranial aneurysm rupture.
J Cereb Blood Flow Metab
; 44(7): 1174-1183, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38241458
ABSTRACT
Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D deficiency promotes aneurysm rupture and examined the underlying mechanism for the protective role of vitamin D against the development of aneurysm rupture utilizing a mouse model of intracranial aneurysm. Mice consuming a vitamin D-deficient diet had a higher rupture rate than mice with a regular diet. Vitamin D deficiency increased proinflammatory cytokines in the cerebral arteries. Concurrently, vitamin D receptor knockout mice had a higher rupture rate than the corresponding wild-type littermates. The vitamin D receptors on endothelial and vascular smooth muscle cells, but not on hematopoietic cells, mediated the effect of aneurysm rupture. Our results establish that vitamin D protects against the development of aneurysmal rupture through the vitamin D receptors on vascular endothelial and smooth muscle cells. Vitamin D supplementation may be a viable pharmacologic therapy for preventing aneurysm rupture.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Intracranial Aneurysm
/
Aneurysm, Ruptured
/
Receptors, Calcitriol
/
Mice, Knockout
Limits:
Animals
Language:
En
Journal:
J Cereb Blood Flow Metab
/
J. cereb. blood flow metab
/
Journal of cerebral blood flow and metabolism
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Estados Unidos