Your browser doesn't support javascript.
loading
Mo' m1A, mo' problems.
Miller, Linamarie; Shorter, James.
Affiliation
  • Miller L; Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shorter J; Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@pennmedicine.upenn.edu.
Cell Chem Biol ; 31(1): 14-16, 2024 01 18.
Article in En | MEDLINE | ID: mdl-38242092
ABSTRACT
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of TDP-43. These findings suggest therapeutic strategies for CAG-repeat expansion disorders.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Chem Biol / Cell Chem. Biol / Cell chemical biology (Online) Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Chem Biol / Cell Chem. Biol / Cell chemical biology (Online) Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos