Blood Eosinophil Count and Its Determinants in a Chinese Population-Based Cohort.
Respiration
; 103(2): 70-78, 2024.
Article
in En
| MEDLINE
| ID: mdl-38253034
ABSTRACT
INTRODUCTION:
Blood eosinophil count has been shown markedly variable across different populations. However, its distribution in Chinese general population remains unclear. We aimed to investigate blood eosinophil count and its determinants in a Chinese general population.METHODS:
In this population-based study, general citizens of Sichuan province in China were extracted from the China Pulmonary Health study. Data on demographics, personal and family history, living condition, lifestyle, spirometry, and complete blood count test were obtained and analyzed. A stepwise multivariate binary logistic regression analysis was performed to identify determinants of high blood eosinophils (>75th percentile).RESULTS:
A total of 3,310 participants were included, with a mean age (standard deviation) of 47.0 (15.6) years. In total population, the median blood eosinophil count was 110.0 (interquartile range [IQR] 67.2-192.9) cells/µL, lower than that in smokers (133.4 cells/µL, IQR 79.3-228.4) and patients with asthma (140.7 cells/µL, IQR 79.6-218.2) or post-bronchodilator airflow limitation (141.5 cells/µL, IQR 82.6-230.1), with a right-skewed distribution. Multivariate analyses revealed that oldness (aged ≥60 years) (odds ratio [OR] 1.66, 95% confidence interval [CI] 1.11-2.48), smoking ≥20 pack-years (OR 1.90, 95% CI 1.20-3.00), raising a dog/cat (OR 1.72, 95% CI 1.17-2.52), and occupational exposure to dust, allergen, and harmful gas (OR 1.58, 95% CI 1.15-2.15) were significantly associated with high blood eosinophils.CONCLUSION:
This study identifies a median blood eosinophil count of 110.0 cells/µL and determinants of high blood eosinophils in a Chinese general population, including oldness (aged ≥60 years), smoking ≥20 pack-years, raising a dog/cat, and occupational exposure to dust, allergen, and harmful gas.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Pulmonary Disease, Chronic Obstructive
/
Eosinophilia
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
Respiration
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Suiza