Overcoming NMR line broadening of nitrogen containing compounds: A simple solution.
Magn Reson Chem
; 62(3): 198-207, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38258438
ABSTRACT
This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Magn Reson Chem
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido