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Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats.
Raber, Jacob; Holden, Sarah; Kessler, Kat; Glaeser, Breanna; McQuesten, Chloe; Chaudhari, Mitali; Stenzel, Fiona; Lenarczyk, Marek; Leonard, Scott Willem; Morré, Jeffrey; Choi, Jaewoo; Kronenberg, Amy; Borg, Alexander; Kwok, Andy; Stevens, Jan Frederik; Olsen, Christopher; Willey, Jeffrey S; Bobe, Gerd; Minnier, Jessica; Baker, John E.
Affiliation
  • Raber J; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • Holden S; Departments of Neurology, and Radiation Medicine, Division of Neuroscience ONPRC, Oregon Health & Science University, Portland, OR, United States.
  • Kessler K; College of Pharmacy, Oregon State University, Corvallis, OR, United States.
  • Glaeser B; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • McQuesten C; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • Chaudhari M; Neuroscience Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.
  • Stenzel F; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • Lenarczyk M; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • Leonard SW; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
  • Morré J; Radiation Biosciences Laboratory, Medical College of Wisconsin, Milwaukee, WI, United States.
  • Choi J; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Kronenberg A; Mass Spectrometry Core, Oregon State University, Corvallis, OR, United States.
  • Borg A; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.
  • Kwok A; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
  • Stevens JF; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Olsen C; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Willey JS; College of Pharmacy, Oregon State University, Corvallis, OR, United States.
  • Bobe G; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.
  • Minnier J; Neuroscience Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.
  • Baker JE; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Front Physiol ; 14: 1316186, 2023.
Article in En | MEDLINE | ID: mdl-38260101
ABSTRACT

Introduction:

The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed the behavioral and cognitive performances of male Fisher rats 2 months after sham irradiation or total body irradiation with photons in the absence or presence of simulated microgravity. We analyzed the plasma collected 9 months after sham irradiation or total body irradiation for distinct alterations in metabolic pathways and to determine whether changes to metabolic measures were associated with specific behavioral and cognitive measures.

Methods:

A total of 344 male Fischer rats were irradiated with photons (6 MeV; 3, 8, or 10 Gy) in the absence or presence of simulated weightlessness achieved using hindlimb unloading (HU). To identify potential plasma biomarkers of photon radiation exposure or the HU condition for behavioral or cognitive performance, we performed regression analyses.

Results:

The behavioral effects of HU on activity levels in an open field, measures of anxiety in an elevated plus maze, and anhedonia in the M&M consumption test were more pronounced than those of photon irradiation. Phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism and biosynthesis showed very strong pathway changes, following photon irradiation and HU in animals irradiated with 3 Gy. Here, 29 out of 101 plasma metabolites were associated with 1 out of 13 behavioral measures. In the absence of HU, 22 metabolites were related to behavioral and cognitive measures. In HU animals that were sham-irradiated or irradiated with 8 Gy, one metabolite was related to behavioral and cognitive measures. In HU animals irradiated with 3 Gy, six metabolites were related to behavioral and cognitive measures.

Discussion:

These data suggest that it will be possible to develop stable plasma biomarkers of behavioral and cognitive performance, following environmental challenges like HU and radiation exposure.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Physiol Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Physiol Year: 2023 Document type: Article Affiliation country: Estados Unidos