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Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein.
McMillan, Christopher L D; Wijesundara, Danushka K; Choo, Jovin J Y; Amarilla, Alberto A; Modhiran, Naphak; Fernando, Germain J P; Khromykh, Alexander A; Watterson, Daniel; Young, Paul R; Muller, David A.
Affiliation
  • McMillan CLD; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Wijesundara DK; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia.
  • Choo JJY; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Amarilla AA; Vaxxas Biomedical Facility, Hamilton, Queensland 4007, Australia.
  • Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Fernando GJP; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Khromykh AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
  • Young PR; Vaxxas Biomedical Facility, Hamilton, Queensland 4007, Australia.
  • Muller DA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
J Gen Virol ; 105(1)2024 01.
Article in En | MEDLINE | ID: mdl-38271027
ABSTRACT
The COVID-19 pandemic has highlighted the need for vaccines capable of providing rapid and robust protection. One way to improve vaccine efficacy is delivery via microarray patches, such as the Vaxxas high-density microarray patch (HD-MAP). We have previously demonstrated that delivery of a SARS-CoV-2 protein vaccine candidate, HexaPro, via the HD-MAP induces potent humoral immune responses. Here, we investigate the cellular responses induced by HexaPro HD-MAP vaccination. We found that delivery via the HD-MAP induces a type one biassed cellular response of much greater magnitude as compared to standard intramuscular immunization.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Animals / Humans Language: En Journal: J Gen Virol / J. gen. virol / Journal of general virology Year: 2024 Document type: Article Affiliation country: Australia Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Animals / Humans Language: En Journal: J Gen Virol / J. gen. virol / Journal of general virology Year: 2024 Document type: Article Affiliation country: Australia Country of publication: Reino Unido