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Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.
Koyanagi, Yuriko N; Nakatochi, Masahiro; Namba, Shinichi; Oze, Isao; Charvat, Hadrien; Narita, Akira; Kawaguchi, Takahisa; Ikezaki, Hiroaki; Hishida, Asahi; Hara, Megumi; Takezaki, Toshiro; Koyama, Teruhide; Nakamura, Yohko; Suzuki, Sadao; Katsuura-Kamano, Sakurako; Kuriki, Kiyonori; Nakamura, Yasuyuki; Takeuchi, Kenji; Hozawa, Atsushi; Kinoshita, Kengo; Sutoh, Yoichi; Tanno, Kozo; Shimizu, Atsushi; Ito, Hidemi; Kasugai, Yumiko; Kawakatsu, Yukino; Taniyama, Yukari; Tajika, Masahiro; Shimizu, Yasuhiro; Suzuki, Etsuji; Hosono, Yasuyuki; Imoto, Issei; Tabara, Yasuharu; Takahashi, Meiko; Setoh, Kazuya; Matsuda, Koichi; Nakano, Shiori; Goto, Atsushi; Katagiri, Ryoko; Yamaji, Taiki; Sawada, Norie; Tsugane, Shoichiro; Wakai, Kenji; Yamamoto, Masayuki; Sasaki, Makoto; Matsuda, Fumihiko; Okada, Yukinori; Iwasaki, Motoki; Brennan, Paul; Matsuo, Keitaro.
Affiliation
  • Koyanagi YN; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
  • Oze I; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Charvat H; Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan.
  • Narita A; Division of International Health Policy Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
  • Kawaguchi T; Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
  • Ikezaki H; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Hishida A; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Hara M; Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.
  • Takezaki T; Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Koyama T; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nakamura Y; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
  • Suzuki S; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Katsuura-Kamano S; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Kuriki K; Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan.
  • Nakamura Y; Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Takeuchi K; Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
  • Hozawa A; Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • Kinoshita K; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.
  • Sutoh Y; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Tanno K; Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan.
  • Shimizu A; Division for Regional Community Development, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
  • Ito H; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kasugai Y; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kawakatsu Y; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
  • Taniyama Y; Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.
  • Tajika M; Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
  • Shimizu Y; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
  • Suzuki E; Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.
  • Hosono Y; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Imoto I; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Tabara Y; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Takahashi M; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Setoh K; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Matsuda K; Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan.
  • Nakano S; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
  • Goto A; Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
  • Katagiri R; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Yamaji T; Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
  • Sawada N; Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Tsugane S; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Wakai K; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
  • Yamamoto M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Sasaki M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Matsuda F; Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Okada Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Iwasaki M; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
  • Brennan P; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
  • Matsuo K; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Japan.
Sci Adv ; 10(4): eade2780, 2024 Jan 26.
Article in En | MEDLINE | ID: mdl-38277453
ABSTRACT
An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (GCKR, KLB, and ADH1B) in wild-type homozygotes and six (GCKR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, and GOT2) in heterozygotes, with five showing genome-wide significant interaction with rs671. Genetic correlation analyses revealed ancestry-specific genetic architecture in heterozygotes. Of the discovered loci, four (GCKR, ADH1B, ALDH1A1, and ALDH2) were suggested to interact with rs671 in the risk of esophageal cancer, a representative alcohol-related disease. Our results identify the genotype-specific genetic architecture of alcohol consumption and reveal its potential impact on alcohol-related disease risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Genome-Wide Association Study / East Asian People Type of study: Etiology_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Genome-Wide Association Study / East Asian People Type of study: Etiology_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos