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Acute undifferentiated leukemia with undifferentiated myeloid sarcoma: Case report and literature review.
Luo, Lan; Wang, Xiaoqing; Luo, Ji; Zheng, Shuai; Gong, Ninghan; He, Yuan; Xi, Qian; Chen, Jiao; Jiang, Tao; Zhong, Ling.
Affiliation
  • Luo L; College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
  • Wang X; Department of Hematology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
  • Luo J; University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
  • Zheng S; University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
  • Gong N; University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
  • He Y; Department of Clinical and Experimental Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
  • Xi Q; Department of Clinical and Experimental Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
  • Chen J; Department of pathology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
  • Jiang T; Department of pathology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
  • Zhong L; Human Disease Genes Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Medicine (Baltimore) ; 103(4): e36948, 2024 Jan 26.
Article in En | MEDLINE | ID: mdl-38277531
ABSTRACT

BACKGROUND:

With the advancement of diagnostic technology, true acute undifferentiated leukemia (AUL) is becoming more rare, and AUL with extramedullary sarcoma has not been reported. CASE PRESENTATION This article reports a case of AUL with extramedullary sarcoma. Flow cytometric analysis of the bone marrow and lymph nodes indicated that the tumor cells of both were of the same origin and mainly expressed stem cell markers and CD7, no myeloid-specific markers, T-lymphoblastic-related markers, and B-lymphoblastic-related markers. Although the priming regimen combined with azacitidine was ineffective, complete remission was achieved by switching to azacitidine combined with HIA (homoharringtonine, idarubicin plus Ara-C).

CONCLUSION:

To diagnosis de novo acute leukemia with extensive and comprehensive cellular immune maker detection is available and credible, the expression of a single relatively nonspecific myeloid antigen as a immune maker to detect AUL or AUL associated with sarcoma is precise and effective in our case, which patient was benefit from HIA regiment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Leukemia / Sarcoma, Myeloid Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Medicine (Baltimore) Year: 2024 Document type: Article Affiliation country: China Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Leukemia / Sarcoma, Myeloid Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Medicine (Baltimore) Year: 2024 Document type: Article Affiliation country: China Country of publication: Estados Unidos