Autoimmune thyroid disease in patients with type 1 diabetes mellites: A cross-sectional study from Syria.
Medicine (Baltimore)
; 103(4): e36107, 2024 Jan 26.
Article
in En
| MEDLINE
| ID: mdl-38277548
ABSTRACT
The present study aimed to investigate the occurrence of autoimmune thyroid disease (AITD) in patients with type 1 diabetes mellitus (T1DM) by the presence of antithyroid peroxidase (anti-TPO Ab). Furthermore, we studied the relationship of clinical and thyroid ultrasound (US) characteristics with anti-TPO Ab. This cross-sectional study was performed in Al- Mowasat and Al-Assad University Hospitals from 2021 to 2023. Clinical, laboratories, and US features were collected and analyzed between positive compared to negative anti-TPO Ab. Of 76 patients, anti-TPO Ab was positive in 12 patients (15.7%) with female predominance [nâ
=â
10 (83.3%)]. Gender showed a difference between anti-TPO Ab groups (Pâ
=â
.026). DM duration showed a difference (Pâ
=â
.034), which was dominant for a group of positive anti-TPO Ab (medianâ
=â
9). The age at DM diagnosis also showed a difference (Pâ
=â
.048), where most patients were under 10- years old at diagnosis [nâ
=â
39 (51.3%)] and the highest number of anti-TPO Ab positive patients [nâ
=â
7 (58.3%)] were in this age category. US findings showed a significant difference (Pâ
=â
.001). Regarding positive anti-TPO Ab patients, the most frequent US finding was immune pattern [7 (58.3%)], which was more common than in the negative group (12.5%). Age, hemoglobin A1c (HBA1c), and body mass index (BMI) did not present differences (Pâ
=â
.391, 0.692, and 0.453, respectively), however, all anti-TPO Ab positive patients were older than ten years and had HBA1c more than 8. Thyroid-stimulating hormone (TSH) was abnormal in 2 patients (16.6%) and both in anti-TPO Ab positive group. This study suggests that anti-TPO Ab appears in older patients and with longer MD duration. Also, data support using US and anti-TPO Ab as earlier markers for AITDs, and further recommending regular annual monitoring by US and anti-TPO Ab in all patients with T1DM for AITDs diagnosis, especially in females.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 1
/
Hashimoto Disease
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Medicine (Baltimore)
Year:
2024
Document type:
Article
Affiliation country:
Siria