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Brain glutathione and GABA+ levels in autistic children.
Song, Yulu; Hupfeld, Kathleen E; Davies-Jenkins, Christopher W; Zöllner, Helge J; Murali-Manohar, Saipavitra; Mumuni, Abdul Nashirudeen; Crocetti, Deana; Yedavalli, Vivek; Oeltzschner, Georg; Alessi, Natalie; Batschelett, Mitchell A; Puts, Nicolaas A J; Mostofsky, Stewart H; Edden, Richard A E.
Affiliation
  • Song Y; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hupfeld KE; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Davies-Jenkins CW; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Zöllner HJ; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Murali-Manohar S; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Mumuni AN; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Crocetti D; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Yedavalli V; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Oeltzschner G; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Alessi N; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Batschelett MA; Department of Medical Imaging, University for Development Studies, Tamale, Ghana.
  • Puts NAJ; Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Mostofsky SH; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Edden RAE; The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Autism Res ; 17(3): 512-528, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38279628
ABSTRACT
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA), have been proposed as potential contributors to the biology underlying ASD. This study investigated whether cerebral GSH or GABA levels differ between a cohort of children aged 8-12 years with ASD (n = 52) and typically developing children (TDC, n = 49). A comprehensive analysis of GSH and GABA levels in multiple brain regions, including the primary motor cortex (SM1), thalamus (Thal), medial prefrontal cortex (mPFC), and supplementary motor area (SMA), was conducted using single-voxel HERMES MR spectroscopy at 3T. The results revealed no significant differences in cerebral GSH or GABA levels between the ASD and TDC groups across all examined regions. These findings suggest that the concentrations of GSH (an important antioxidant and neuromodulator) and GABA (a major inhibitory neurotransmitter) do not exhibit marked alterations in children with ASD compared to TDC. A statistically significant positive correlation was observed between GABA levels in the SM1 and Thal regions with ADHD inattention scores. No significant correlation was found between metabolite levels and hyper/impulsive scores of ADHD, measures of core ASD symptoms (ADOS-2, SRS-P) or adaptive behavior (ABAS-2). While both GSH and GABA have been implicated in various neurological disorders, the current study provides valuable insights into the specific context of ASD and highlights the need for further research to explore other neurochemical alterations that may contribute to the pathophysiology of this complex disorder.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Autism Spectrum Disorder Limits: Child / Humans Language: En Journal: Autism Res Journal subject: PSIQUIATRIA / TRANSTORNOS MENTAIS Year: 2024 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Autism Spectrum Disorder Limits: Child / Humans Language: En Journal: Autism Res Journal subject: PSIQUIATRIA / TRANSTORNOS MENTAIS Year: 2024 Document type: Article Affiliation country: Estados Unidos