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Activation of GPR3-ß-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis.
Dong, Ting; Hu, Guangan; Fan, Zhongqi; Wang, Huirui; Gao, Yinghui; Wang, Sisi; Xu, Hao; Yaffe, Michael B; Vander Heiden, Matthew G; Lv, Guoyue; Chen, Jianzhu.
Affiliation
  • Dong T; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Hu G; Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Fan Z; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. gahu@mit.edu.
  • Wang H; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Gao Y; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
  • Wang S; Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Xu H; Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Yaffe MB; Department of Translational Medicine, The First Hospital of Jilin University, Changchun, 130061, China.
  • Vander Heiden MG; Department of Translational Medicine, The First Hospital of Jilin University, Changchun, 130061, China.
  • Lv G; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Chen J; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Nat Commun ; 15(1): 807, 2024 Jan 27.
Article in En | MEDLINE | ID: mdl-38280848
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Kupffer Cells Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Kupffer Cells Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido