Effect of Egg-White Protein Alone or Combined With Niacin on Nutritional Status, and Phosphorus Control in Maintenance Hemodialysis Patients: A Randomized Controlled Trial.
J Ren Nutr
; 34(4): 350-358, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38281653
ABSTRACT
OBJECTIVE:
Niacin is reported to decrease phosphorus concentration in maintenance hemodialysis (MHD) patients. Egg white is one of the main substitutable proteins in MHD patients due to its low phosphorus content. Therefore, we aimed to evaluate the effects of combined egg white and niacin supplementation on dialysis patients' serum phosphorus and nutritional biomarkers. DESIGN ANDMETHODS:
In this randomized controlled clinical trial, 98 patients on MHD were randomly allocated to four groups for 8 weeks 24 g egg white (n = 25), 600 g niacin daily (n = 24), egg white combined with niacin (n = 24), and control (n = 24). Calcium, phosphorus, fibroblast growth factor-23, and other nutritional markers were assessed.RESULTS:
There was a significant difference among the groups only in phosphorus at the end of the trial, which was significantly lower in the niacin group (4.38 + 0.812 mg/dL) than in both the egg white (5.07 + 0.49 mg/dL) and egg white with niacin supplementation (5.41 + 0.662 mg/dL) groups. In this regard, albumin increased in egg white and egg white with niacin supplementation, while albumin did not change significantly in the niacin group. Urea reduction ratio and Kt/V rose only in the egg-white group, while aspartate aminotransferase increased only in the niacin and control groups.CONCLUSION:
Niacin decreases serum phosphorus concentration more than egg-white protein or a combined intervention. Egg white protein supplementation has beneficial effects on some nutritional statuses other than phosphorus control without the side effects of niacin.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphorus
/
Nutritional Status
/
Renal Dialysis
/
Dietary Supplements
/
Niacin
Type of study:
Clinical_trials
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Ren Nutr
Journal subject:
CIENCIAS DA NUTRICAO
/
NEFROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Irán
Country of publication:
Estados Unidos