Eudesmane sesquiterpenoids with inhibitory effects on NO production from Artemisia princeps.
Phytochemistry
; 220: 113999, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38281703
ABSTRACT
Five undescribed eudesmane methyl esters (1-5), three undescribed eudesmane-12,6-olides (6-8), and 21 known analogues (9-29) were isolated from the aerial part of Artemisia princeps Pamp. Their structures were established by detailed analysis of the NMR and HRESIMS data. The absolute configurations of 1-8 were determined based on single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory effects on LPS-induced NO production in BV-2 microglial cells of all the isolated compounds were assessed. Except for compounds 2, 4, 10, and 11, the others showed significant inhibitory activities, with IC50 values of 0.73-18.66 µM, wherein the potential structure-activity relationship was also discussed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Artemisia
/
Sesquiterpenes, Eudesmane
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Country of publication:
Reino Unido