Targeting virus-specific CD8+ T cells for treatment of chronic viral hepatitis: from bench to bedside.
Expert Opin Biol Ther
; 24(1-2): 77-89, 2024.
Article
in En
| MEDLINE
| ID: mdl-38290716
Chronic viral hepatitis is a global health issue with an urgent need for new therapeutic approaches. Cytotoxic T killer cells (virus-specific CD8+ T cells) are key players in mediating control of viral hepatitis, and chronic infection is associated with dysfunction of these cells. Therefore, reconstitution of virus-specific CD8+ T cells by immunotherapy is an interesting therapeutic approach for chronic viral hepatitis. In this review, we will compare data on different mechanisms contributing to CD8+ T cell dysfunction in chronic hepatitis B, C, D, and E virus infection, respectively. Furthermore, preclinical and clinical studies for the individual hepatitis viruses will be discussed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Hepatitis B, Chronic
/
Liver Neoplasms
Limits:
Humans
Language:
En
Journal:
Expert Opin Biol Ther
Journal subject:
BIOLOGIA
/
TERAPEUTICA
Year:
2024
Document type:
Article
Affiliation country:
Alemania
Country of publication:
Reino Unido