Isolation of metastatic B16 melanoma variants using anti-Met 72 monoclonal antibodies and flow cytometry.
Clin Exp Metastasis
; 5(1): 35-42, 1987.
Article
in En
| MEDLINE
| ID: mdl-3829495
ABSTRACT
Analysis of a number of B16 melanoma clones has revealed a high correlation between metastatic activity and the quantitative expression of a 72,000 dalton glycoprotein, Met 72. In the present study, metastatic tumor cell variants have been directly isolated from a heterogeneous, poorly metastatic melanoma (B16-F1) by anti-Met 72 monclonal antibodies and cell sorting procedures. These studies provide direct proof that Met-72 antigens are in fact surface markers of B16 melanoma metastatic variants and may provide the means of monitoring their presence, influence and autonomy during tumor progression.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Melanoma, Experimental
/
Antibodies, Monoclonal
Limits:
Animals
Language:
En
Journal:
Clin Exp Metastasis
Journal subject:
NEOPLASIAS
Year:
1987
Document type:
Article