Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.
Neuro Endocrinol Lett
; 45(1): 76-80, 2024 Jan 31.
Article
in En
| MEDLINE
| ID: mdl-38295430
ABSTRACT
INTRODUCTION:
Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain. CASE DESCRIPTION A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.CONCLUSION:
This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Neoplasms
/
Neuroendocrine Tumors
/
Pituitary ACTH Hypersecretion
/
Kidney Neoplasms
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Neuro Endocrinol Lett
/
Neuroendocrinol. lett
/
Neuroendocrinology letters
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Suecia