Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges.
Drug Resist Updat
; 73: 101053, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38301487
ABSTRACT
Viral infections have a major impact in human health. Ongoing viral transmission and escalating selective pressure have the potential to favor the emergence of vaccine- and antiviral drug-resistant viruses. Target-based approaches for the design of antiviral drugs can play a pivotal role in combating drug-resistant challenges. Drug design computational tools facilitate the discovery of novel drugs. This review provides a comprehensive overview of current drug design strategies employed in the field of antiviral drug resistance, illustrated through the description of a series of successful applications. These strategies include technologies that enhance compound-target affinity while minimizing interactions with mutated binding pockets. Furthermore, emerging approaches such as virtual screening, targeted protein/RNA degradation, and resistance analysis during drug design have been harnessed to curtail the emergence of drug resistance. Additionally, host targeting antiviral drugs offer a promising avenue for circumventing viral mutation. The widespread adoption of these refined drug design strategies will effectively address the prevailing challenge posed by antiviral drug resistance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Drug Design
Limits:
Humans
Language:
En
Journal:
Drug Resist Updat
Journal subject:
ANTINEOPLASICOS
Year:
2024
Document type:
Article
Country of publication:
Reino Unido