Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 9(5): 472-489, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38301886
ABSTRACT
Psychedelic compounds, including psilocybin, LSD (lysergic acid diethylamide), DMT (N,N -dimethyltryptamine), and 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), all of which are serotonin 2A receptor agonists, are being investigated as potential treatments. This review aims to summarize the current clinical research on these 4 compounds and mescaline to guide future research. Their mechanism(s) of action, pharmacokinetics, pharmacodynamics, efficacy, and safety were reviewed. While evidence for therapeutic indications, with the exception of psilocybin for depression, is still relatively scarce, we noted no differences in psychedelic effects beyond effect duration. Therefore, it remains unclear whether different receptor profiles contribute to the therapeutic potential of these compounds. More research is needed to differentiate these compounds in order to inform which compounds might be best for different therapeutic uses.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psilocybin
/
Hallucinogens
/
Lysergic Acid Diethylamide
Limits:
Humans
Language:
En
Journal:
Biol Psychiatry Cogn Neurosci Neuroimaging
Year:
2024
Document type:
Article