Isolation and characterization of seven neovibsane-type diterpenoids from Viburnum odoratissimum and their neuroblastoma cell protective effects.
Phytochemistry
; 220: 113992, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38301947
ABSTRACT
Seven undescribed neovibsane-type diterpenoids (1-7) were isolated from the leaves of Viburnum odoratissimum. Their planar structures and relative configurations were elucidated based on a combination of 1D and 2D NMR analysis. The absolute configurations were confirmed by Rh2(OCOCF3)4-induced ECD analysis and comparison of experimental and TDDFT-calculated ECD spectrum. Based on the empirical results of the ECD of in situ formed Rh-complexes, rapid determination of the absolute configuration of C-14 within vibsane-type diterpenoids was proposed. In addition, 3 exhibited a high neuroblastoma cell protective effect of 81.8 % at 50 µM (the control group showed a neuroblastoma cell protective effect of 56.2 % at 50 µM).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viburnum
/
Diterpenes
/
Neuroblastoma
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article