Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease.
Am J Pathol
; 194(5): 628-636, 2024 05.
Article
in En
| MEDLINE
| ID: mdl-38309429
ABSTRACT
Neutrophils are an important cell type often considered the body's first responders to inflammatory insult or damage. They are recruited to the tissue of the lungs in patients with inflammatory airspace diseases and have unique and complex functions that range from helpful to harmful. The uniqueness of these functions is due to the heterogeneity of the inflammatory cascade and retention in the vasculature. Neutrophils are known to marginate, or remain stagnant, in the lungs even in nondisease conditions. This review discusses the ways in which the recruitment, presence, and function of neutrophils in the airspace of the lungs are unique from those of other tissues, and the complex effects of neutrophils on pathogenesis. Inflammatory mediators produced by neutrophils, such as neutrophil elastase, proresolving mediators, and neutrophil extracellular traps, dramatically affect the outcomes of patients with disease of the lungs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Extracellular Traps
/
Neutrophils
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Am J Pathol
/
Am. j. pathol
/
American journal of pathology
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos