Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022.
Emerg Infect Dis
; 30(3): 432-443, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38325363
ABSTRACT
During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Monkeypox virus
/
Mpox (monkeypox)
Type of study:
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Emerg Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA