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Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model.
Vlasblom, Ronald; van Thiel, Jory; Bittenbinder, Matyas A; van Rhijn, Jon-Ruben; Drost, Rinske; Muis, Lotte; Slagboom, Julien; Salvatori, Daniela; Kool, Jeroen; Veldman, Robert Jan.
Affiliation
  • Vlasblom R; Institute of Life Sciences and Chemistry, HU University of Applied Sciences, 3584 CS, Utrecht, the Netherlands. Electronic address: ronald.vlasblom@hu.nl.
  • van Thiel J; Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden, the Netherlands.
  • Bittenbinder MA; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.
  • van Rhijn JR; Institute of Life Sciences and Chemistry, HU University of Applied Sciences, 3584 CS, Utrecht, the Netherlands.
  • Drost R; Institute of Life Sciences and Chemistry, HU University of Applied Sciences, 3584 CS, Utrecht, the Netherlands.
  • Muis L; Institute of Life Sciences and Chemistry, HU University of Applied Sciences, 3584 CS, Utrecht, the Netherlands.
  • Slagboom J; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.
  • Salvatori D; Anatomy and Physiology, Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, the Netherlands.
  • Kool J; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.
  • Veldman RJ; Institute of Life Sciences and Chemistry, HU University of Applied Sciences, 3584 CS, Utrecht, the Netherlands.
Toxicon ; 240: 107637, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38331109
ABSTRACT
Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotalid Venoms / Naja / Venomous Snakes Limits: Animals Language: En Journal: Toxicon Year: 2024 Document type: Article Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotalid Venoms / Naja / Venomous Snakes Limits: Animals Language: En Journal: Toxicon Year: 2024 Document type: Article Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM