What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?
Lipids Health Dis
; 23(1): 41, 2024 Feb 08.
Article
in En
| MEDLINE
| ID: mdl-38331795
ABSTRACT
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver disease, alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). Although AFLD and NAFLD are similar in their initial morphological features, both conditions involve the same evolutive forms. Moreover, there are various common mechanisms underlying both diseases, including alcoholic liver disease and NAFLD, which are commonalities. In this Review, the authors explore similar downstream signaling events involved in the onset and progression of the two entities but not completely different entities, predominantly focusing on the gut microbiome. Downstream molecular events, such as the roles of sirtuins, cytokeratins, adipokines and others, should be considered. Finally, to complete the feature, some new tendencies in the therapeutic approach are presented.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fatty Liver, Alcoholic
/
Non-alcoholic Fatty Liver Disease
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Lipids Health Dis
/
Lipids health dis. (Online)
/
Lipids in health and disease (Online)
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Reino Unido