Efficacy of a new water-free topical cyclosporine 0.1% solution for optimizing the ocular surface in patients with dry eye and cataract.
J Cataract Refract Surg
; 50(6): 644-650, 2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38334413
ABSTRACT
This is a pooled analysis from 2 phase III clinical trials investigating a water-free topical cyclosporine 0.1% for the treatment of moderate to severe dry eye. The analyses included 1162 patients 35% with cataract, 20% with pseudophakia, and 45% without cataract. Demographics or baseline characteristics were comparable across groups except for age and vision. The cyclosporine-treated patients achieved large mean improvements from baseline by day 15 -3.7 in patients without cataract, -3.2 in patients with cataract, and -3.1 in pseudophakic patients. These improvements were statistically significantly higher compared with the respective vehicle groups. In the cataract subgroup, 59% of patients treated with cyclosporine achieved ≥3 grade improvements in corneal staining score, as early as day 15. The magnitude of the effect and early onset of action make this new cyclosporine solution a promising candidate for preoperative management of ocular surface in patients undergoing cataract surgery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ophthalmic Solutions
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Dry Eye Syndromes
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Cyclosporine
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Pseudophakia
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Immunosuppressive Agents
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Cataract Refract Surg
Journal subject:
OFTALMOLOGIA
Year:
2024
Document type:
Article