New Approaches for the Treatment of AML beyond the 7+3 Regimen: Current Concepts and New Approaches.
Cancers (Basel)
; 16(3)2024 Feb 05.
Article
in En
| MEDLINE
| ID: mdl-38339429
ABSTRACT
Fifty years have passed since the development of the first chemotherapy regimen for treating acute myelogenous leukemia (AML), with the approval in 1973 of the cytarabine daunorubicin (7+3) regimen. Until recently, patients diagnosed with AML had very limited treatment options and depended primarily on chemotherapy in combinations, doses, or schedules of the same drugs. Patients with advanced age, comorbidities, or relapsed or refractory disease were left with no effective options for treatment. New advances in the understanding of the biology and the molecular and genetic changes associated with leukemogenesis, as well as recent advances in drug development, have resulted in the introduction over the last few years of novel therapeutic agents and approaches to the treatment of AML as well as a new classification of the disease. In this article, we will discuss the new classification of AML; the mechanisms, actions, and indications of the new targeted therapies; the chemotherapy combinations; and the potential role of cellular therapies as new treatment options for this terrible disease.
AMLacute myelogenous leukemia; CBUcord blood unit; ELNEuropean Leukemia Network; GVHDgraft-versus-host disease; ICCInternational Consensus Classification; LDAClow-dose cytarabine; MDSmyelodysplastic syndrome; MRDminimal residual disease; NGSnext-generation sequencing; NRMnonrelapse mortality; OSoverall survival; PBSCsperipheral blood stem cells; PTCypost-transplant cyclophosphamide; RFSrelapsed free survival; WHOWorld Health Organization; allo-HCTallogeneic stem cell transplant
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cancers (Basel)
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos