FLASH radiotherapy: A new milestone in the field of cancer radiotherapy.
Cancer Lett
; 587: 216651, 2024 Apr 10.
Article
in En
| MEDLINE
| ID: mdl-38342233
ABSTRACT
Radiotherapy plays a pivotal role in the control and eradication of tumors, but it can also induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent years, FLASH-Radiotherapy (FLASH-RT) has emerged as a cutting-edge research focus in the field of radiation therapy. By delivering high radiation doses to the treatment target in an ultra-short time, FLASH-RT produces the FLASH effect, which reduces the toxicity to normal tissues while achieving comparable tumor control efficacy to conventional radiotherapy. This review provides a brief overview of the development history of FLASH-RT and its impact on tumor control. Additionally, it focuses on introducing the protective effects and molecular mechanisms of this technology on various normal tissues, as well as exploring its synergistic effects when combined with other tumor therapies. Importantly, this review discusses the challenges faced in translating FLASH-RT into clinical practice and outlines its promising future applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Radiation Oncology
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer Lett
/
Cancer lett
/
Cancer letters
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Irlanda