Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH.
Virus Res
; 342: 199336, 2024 04.
Article
in En
| MEDLINE
| ID: mdl-38342315
ABSTRACT
Enterovirus 71 (EV71) is the common causative agent of hand-foot-mouth disease (HFMD). Despite evidence in mice model suggested that the interferon (IFN) signaling pathways play a role in defending against this virus, knowledge on the IFN-mediated antiviral response is still limited. Here we identified an IFN-stimulated gene (ISG) called L3HYPDH, whose expression inhibits EV71 replication. Mapping assay indicated that amino acids 61-120 and 295-354 are critical for its optimal antiviral activity. Mechanismly, L3HYPDH specifically inhibits protein translation mediated by EV71 internal ribosome entry site (IRES). Our data thus uncovered a new mechanism utilized by the host cell to restrict EV71 replication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interferons
/
Hand, Foot and Mouth Disease
Limits:
Animals
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China