Acyclovir-Induced Nephrotoxicity in Adults with Viral Encephalitis.
J Coll Physicians Surg Pak
; 34(2): 151-155, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38342863
ABSTRACT
OBJECTIVE:
To determine the frequency of parenteral Acyclovir-induced Acute Kidney Injury (AKI) in patients with viral encephalitis. STUDYDESIGN:
Descriptive study. Place and Duration of the Study Department of Neurology, Liaquat National Hospital, Karachi, from January to December 2021.METHODOLOGY:
A total of 89 suspected and proven cases of encephalitis receiving IV Acyclovir were collated. All had extensive medical histories and underwent CSF studies with +/- brain imaging. CSF routine and viral PCR were done. Acyclovir-induced AKI was defined as a rise in serum creatinine of >0.3 mg/dl in 48 h or by ≥1.5 times the baseline value, and its severity was staged into 1 (risk), 2 (injury), and 3 (failure) according to the KDIGO guidelines (Kidney Disease Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group, 2012). Patients' variables, including age, gender, presenting features, comorbid conditions, and CSF findings, were divided into two groups, i.e. with and without AKI.RESULTS:
This research included 89 patients with a mean age of 48 years. AKI occurred in 34 patients (38.2%). The frequency of AKI with Stage 1 was 24%, Stage 2 was 44%, and Stage 3 was 32%; approximately two-thirds of cases were in Stage 2 and 3 (p >0.05). Five patients (5.6%) from Stage 3, required dialysis.CONCLUSION:
AKI is an important adverse effect of parenteral acyclovir, which necessitates its early identification and timely management. Renal function monitoring is essential for patients on Acyclovir treatment as they are at risk for AKI. KEY WORDS Acyclovir, Acute kidney injury, Viral encephalitis, Creatinine, Kidney Disease Improving Global Outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Encephalitis, Viral
/
Drug-Related Side Effects and Adverse Reactions
/
Acute Kidney Injury
Type of study:
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
J Coll Physicians Surg Pak
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
Pakistán