Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells.
Proc Natl Acad Sci U S A
; 121(8): e2318030121, 2024 Feb 20.
Article
in En
| MEDLINE
| ID: mdl-38346182
ABSTRACT
The circadian clock throughout the day organizes the activity of neural stem cells (NSCs) in the dentate gyrus (DG) of adult hippocampus temporally. However, it is still unclear whether and how circadian signals from the niches contribute to daily rhythmic variation of NSC activation. Here, we show that norepinephrinergic (NEergic) projections from the locus coeruleus (LC), a brain arousal system, innervate into adult DG, where daily rhythmic release of norepinephrine (NE) from the LC NEergic neurons controlled circadian variation of NSC activation through ß3-adrenoceptors. Disrupted circadian rhythmicity by acute sleep deprivation leads to transient NSC overactivation and NSC pool exhaustion over time, which is effectively ameliorated by the inhibition of the LC NEergic neuronal activity or ß3-adrenoceptors-mediated signaling. Finally, we demonstrate that NE/ß3-adrenoceptors-mediated signaling regulates NSC activation through molecular clock BMAL1. Therefore, our study unravels that adult NSCs precisely coordinate circadian neural circuit and intrinsic molecular circadian clock to adapt their cellular behavior across the day.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neural Stem Cells
/
Circadian Clocks
Limits:
Adult
/
Humans
Language:
En
Journal:
Proc Natl Acad Sci U S A
/
Proc. Natl. Acad. Sci. U. S. A
/
Proceedings of the national academy of sciences of the United States of America
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos