A Facile and Green Approach for the Preparation of Amine-Functionalized Poly(ethylene glycol) by Reducing Poly(ethylene glycol) Azide with Dithiothreitol.

Zhang, Xuemei; Geng, Chao; Fu, Yang; Lv, Zhen; Wei, Zhonglin; Wang, Hongda; Wang, Shixue

Zhang, Xuemei; Geng, Chao; Fu, Yang; Lv, Zhen; Wei, Zhonglin; Wang, Hongda; Wang, Shixue.

Affiliation

Zhang X; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Geng C; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Fu Y; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Lv Z; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Wei Z; Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, Jilin, P.R. of China.
Wang H; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Wang S; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.

Biomacromolecules ; 25(3): 1972-1977, 2024 Mar 11.

Article in En | MEDLINE | ID: mdl-38359265

ABSTRACT

ABSTRACT

A facile and green approach for the preparation of PEGn-NH2s from PEGn-N3s in water with DTT as the reduction reagent has been developed, avoiding the introduction of metal ions and difficulties in purification compared to the traditional synthesis process of PEGn-NH2s. A series of high-purity linear and multiarm PEGn-NH2s with different molecular weights were synthesized, demonstrating the versatility of this method. Additionally, HS-PEG45-NH2 with high fidelity of thiol and amine was easily prepared through the one-step two functional group conversion of N3-PEG45-S-S-PEG45-N3, and the PEG-based NH2-PEG@AuNPs were also prepared. This technology will promote the application of PEGn-NH2s in the fields of medicine and biomaterials.

Subject(s)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Metal Nanoparticles Language: En Journal: Biomacromolecules Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Country of publication: Estados Unidos

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google