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Metallic nanoparticles and treatment of cutaneous leishmaniasis: A systematic review.
Guerra, Rhanoica Oliveira; do Carmo Neto, José Rodrigues; da Silva, Priscilla Elias Ferreira; Franco, Pablo Igor Ribeiro; Barbosa, Rafaela Miranda; de Albuquerque Martins, Tarcísio; Costa-Madeira, Juliana; de Assunção, Thais Soares Farnesi; de Oliveira, Carlo José Freire; Machado, Juliana Reis; Silva Teixeira, Luciana de Almeida; Rodrigues, Wellington Francisco; Júnior, Virmondes Rodrigues; Silva, Anielle Christine Almeida; da Silva, Marcos Vinicius.
Affiliation
  • Guerra RO; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP, Brazil.
  • do Carmo Neto JR; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil. Electronic address: rodriguesnneto@gmail.com.
  • da Silva PEF; Post Graduation Course of Tropical Medicine and Infectology, Institute of Healthy Science´s, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • Franco PIR; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania, Goiás, Brazil.
  • Barbosa RM; Department of Basic and Applied Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • de Albuquerque Martins T; Post-Graduation Course of Healthy Science, Institute of Healthy Science, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • Costa-Madeira J; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP, Brazil.
  • de Assunção TSF; Post Graduation Course of Tropical Medicine and Infectology, Institute of Healthy Science´s, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • de Oliveira CJF; Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Brazil.
  • Machado JR; Department of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • Silva Teixeira LA; Department of Internal Medicine, Institute of Healthy Science, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • Rodrigues WF; Post-Graduation Course of Healthy Science, Institute of Healthy Science, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • Júnior VR; Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Brazil.
  • Silva ACA; Laboratory of New Nanostructured and Functional Materials, Physics Institute, Federal University of Alagoas, Maceió, Alagoas, Brazil.
  • da Silva MV; Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Brazil. Electronic address: marcos.silva@uftm.edu.br.
J Trace Elem Med Biol ; 83: 127404, 2024 May.
Article in En | MEDLINE | ID: mdl-38364464
ABSTRACT

BACKGROUND:

Cutaneous leishmaniasis (LC) is an infectious vector-borne disease caused by parasites belonging to the genus Leishmania. Metallic nanoparticles (MNPs) have been investigated as alternatives for the treatment of LC owing to their small size and high surface area. Here, we aimed to evaluate the effect of MNPs in the treatment of LC through experimental, in vitro and in vivo investigations.

METHODS:

The databases used were MEDLINE/ PubMed, Scopus, Web of Science, Embase, and Science Direct. Manual searches of the reference lists of the included studies and grey literature were also performed. English language and experimental in vitro and in vivo studies using different Leishmania species, both related to MNP treatment, were included. This study was registered in PROSPERO (CRD42021248245).

RESULTS:

A total of 93 articles were included. Silver nanoparticles are the most studied MNPs, and L. tropica is the most studied species. Among the mechanisms of action of MNPs in vitro, we highlight the production of reactive oxygen species, direct contact of MNPs with the biomolecules of the parasite, and release of metal ions.

CONCLUSION:

MNPs may be considered a promising alternative for the treatment of LC, but further studies are needed to define their efficacy and safety.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmaniasis, Cutaneous / Metal Nanoparticles Limits: Animals / Humans Language: En Journal: J Trace Elem Med Biol Journal subject: METABOLISMO / SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Brasil Publication country: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmaniasis, Cutaneous / Metal Nanoparticles Limits: Animals / Humans Language: En Journal: J Trace Elem Med Biol Journal subject: METABOLISMO / SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Brasil Publication country: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY