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Wasp venom-induced acute kidney injury: current progress and prospects.
Yu, Fanglin; Wang, Ling; Yuan, Hai; Gao, Zhao; He, Li; Hu, Fengqi.
Affiliation
  • Yu F; School of Medicine, Wuhan University of Science and Technology, Wuhan, China.
  • Wang L; Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Yuan H; Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Gao Z; Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • He L; Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Hu F; Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Ren Fail ; 45(2): 2259230, 2023.
Article in En | MEDLINE | ID: mdl-38376456
ABSTRACT
Wasp venom can trigger local and systemic reactions, with the kidneys being commonly affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our knowledge on the underlying mechanisms of toxicity and targeted therapies remain poor. AKI can result from direct nephrotoxic effects of the wasp venom or secondary rhabdomyolysis and intravascular hemolysis, which will release myoglobin and free hemoglobin. Inflammatory responses play a central role in these pathological mechanisms. Noteworthily, the successful establishment of a suitable experimental model can assist in basic research and clinical advancements related to wasp venom-induced AKI. The combination of therapeutic plasma exchange and continuous renal replacement therapy appears to be the preferred treatment for wasp venom-induced AKI. In addition, studies on cilastatin and varespladib for wasp venom-induced AKI treatment have shown their potential as therapeutic agents. This review summarizes the available evidence on the mechanisms and treatment of wasp venom-induced AKI, with a particular focus on the role of inflammatory responses and potential targets for therapeutic drugs, and, therefore, aiming to support the development of clinical treatment against wasp venom-induced AKI.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wasp Venoms / Acute Kidney Injury Limits: Humans Language: En Journal: Ren Fail Journal subject: NEFROLOGIA Year: 2023 Document type: Article Affiliation country: China Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wasp Venoms / Acute Kidney Injury Limits: Humans Language: En Journal: Ren Fail Journal subject: NEFROLOGIA Year: 2023 Document type: Article Affiliation country: China Country of publication: Reino Unido