Metagenomic Next-Generation Sequencing (mNGS) of cerebrospinal fluid for diagnosis of human herpesvirus 6B encephalitis following transplantation for severe aplastic anemia.
J Infect Dev Ctries
; 18(1): 152-157, 2024 01 31.
Article
in En
| MEDLINE
| ID: mdl-38377081
ABSTRACT
INTRODUCTION:
Human herpesvirus 6B (HHV-6B) encephalitis is common in immunosuppressed patients and presents a diagnostic challenge for physicians. Metagenomic next-generation sequencing (mNGS) may facilitate early diagnosis of HHV-6B encephalitis. Herein, we described a case of HHV-6B encephalitis following transplantation for severe aplastic anemia (SAA) diagnosed by mNGS. CASESUMMARY:
A 31-year-old male underwent myeloablative haploid hematopoietic stem cell transplantation for the treatment of SAA. On day + 21 after transplantation, the patient developed symptoms such as sudden epilepsy, drowsiness, memory dislocation, and memory loss. HHV-6B encephalitis was confirmed based on cranial MRI and mNGS of cerebrospinal fluid. Following antiviral therapy with sodium foscarnet, the symptoms improved and HHV-6B was negative by mNGS. There were no serious sequelae. Currently, the patient is in good health and is still under follow-up.CONCLUSIONS:
A case of HHV-6B encephalitis after SAA transplantation was diagnosed by mNGS of cerebrospinal fluid in time and was effectively treated with sodium foscarnet.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Herpesvirus 6, Human
/
Hematopoietic Stem Cell Transplantation
/
Encephalitis, Viral
/
Roseolovirus Infections
/
Encephalitis
/
Anemia, Aplastic
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Infect Dev Ctries
/
J. infect. dev. ctries
/
Journal of infection in developing countries (Online)
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Italia