Fusion genes in pancreatic tumors.
Trends Cancer
; 10(5): 430-443, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38378317
ABSTRACT
Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events typically detected in KRAS wild-type (WT) pancreatic tumors. Their identification can inform clinical management by enabling precision oncology, as fusions involving BRAF, FGFR2, RET, NTRK, NRG1, and ALK represent actionable targets in KRAS-WT cancers, and serve diagnostic purposes since fusions involving PRKACA/B represent the diagnostic hallmark of intraductal oncocytic papillary neoplasms (IOPNs). Although they are rare, the therapeutic and diagnostic importance of these genomic events should not be underestimated, highlighting the need for quality-ensured molecular diagnostics in the management of cancer. Herein we review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Oncogene Proteins, Fusion
Limits:
Humans
Language:
En
Journal:
Trends Cancer
/
Trends in cancer (Online)
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Estados Unidos