Fenton-like Reaction Inspired "·OH Catalyzed" Osteogenic Process for the Treatment of Osteoporosis.
Adv Healthc Mater
; 13(15): e2304091, 2024 06.
Article
in En
| MEDLINE
| ID: mdl-38381065
ABSTRACT
Inspired by the Fenton-like reaction, this work combines copper peroxide (CP) nanoparticles with black phosphorus (BP) nanosheets to form a hydroxyl radical (·OH)-centered "catalytic" osteogenic system. CP-produced ·OH interacts with BP to rapidly produce a large amount of phosphate ions, thus accelerating self-mineralization and promoting bone formation. In turn, BP not only exerts anti-inflammatory effects, thereby providing a favorable microenvironment for bone formation, but also offsets the potential toxicity of CP induced by reactive oxygen species (ROS). Together with copper ions (Cu2+), phosphate ions are also released as a byproduct of this process, which can contribute to the comprehensive promotion of osteogenesis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteogenesis
/
Osteoporosis
/
Phosphorus
/
Hydroxyl Radical
/
Copper
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Healthc Mater
Year:
2024
Document type:
Article
Affiliation country:
China