MARVEL family proteins contribute to vegetative growth, development, and virulence of the insect fungal pathogen Beauveria bassiana.
J Invertebr Pathol
; 203: 108076, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38382734
ABSTRACT
Beauveria bassiana is one of the most extensively studied entomopathogenic fungi (EPF) and is widely used as a biocontrol agent against various insect pests. Proteins containing the MARVEL domain are conserved in eukaryotes, typically with four transmembrane structures. In this study, we identified the five MARVEL domain proteins in B. bassiana. Five MARVEL domain proteins were localized to cytomembrane and vacuoles in B. bassiana, but had different roles in maintaining the lipid-droplet homeostasis. These proteins were required for fungal virulence, but differentially contributed to fungal utilization of nutrients, stress tolerance, and development under aerial and submerged conditions. Notably, BbMARVEL2 was essential for conidial surface morphology. Additionally, these five MARVEL domain proteins contributed to fungal interaction with the host immune defense. This study provides new mechanistic insights into the life cycle of B. bassiana as a biocontrol agent.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beauveria
Limits:
Animals
Language:
En
Journal:
J Invertebr Pathol
Year:
2024
Document type:
Article
Affiliation country:
China