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Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death.
Wang, Shudan; Kahale, Francesca; Naderi, Amirreza; Surico, Pier Luigi; Yin, Jia; Dohlman, Thomas; Chen, Yihe; Dana, Reza.
Affiliation
  • Wang S; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Kahale F; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
  • Naderi A; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Surico PL; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Yin J; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Dohlman T; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Chen Y; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
  • Dana R; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Biomolecules ; 14(2)2024 Jan 31.
Article in En | MEDLINE | ID: mdl-38397406
ABSTRACT
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-MSH / Melanocortins Limits: Humans Language: En Journal: Biomolecules Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Suiza
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-MSH / Melanocortins Limits: Humans Language: En Journal: Biomolecules Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Suiza