Emergence of Crimean-Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022.
Viruses
; 16(2)2024 02 19.
Article
in En
| MEDLINE
| ID: mdl-38400090
ABSTRACT
Crimean-Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (CCHFV) infection using RT-PCR and for exposure using ELISA. For any CCHF-positive sample, livestock and tick samples were also collected in the neighborhood of the confirmed case and tested using ELISA and RT-PCR, respectively. Genome sequencing and phylogenetic analyses were also performed on samples with positive RT-PCR results. In Eastern Senegal, two human cases and one Hyalomma tick positive for CCHF were identified and a seroprevalence in livestock ranging from 9.33% to 45.26% was detected. Phylogenetic analyses revealed that the human strain belonged to genotype I based on the available L segment. However, the tick strain showed a reassortant profile, with the L and M segments belonging to genotype I and the S segment belonging to genotype III. Our data also showed that our strains clustered with strains isolated in different countries, including Mauritania. Therefore, our findings confirmed the high genetic variability inside the CCHF genotypes and their introduction to Senegal from other countries. They also indicate an increasing CCHF threat in Senegal and emphasize the need to reinforce surveillance using a one-health approach.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ticks
/
Hemorrhagic Fever Virus, Crimean-Congo
/
Hemorrhagic Fever, Crimean
Limits:
Animals
/
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Viruses
Year:
2024
Document type:
Article
Affiliation country:
Senegal
Country of publication:
Suiza