Biochemical evaluation of possible protective effect of purslane extract in experimentally induced arthritis associated with obesity.
Prostaglandins Other Lipid Mediat
; 172: 106823, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38408536
ABSTRACT
Arthritis, a prevalent inflammatory condition, is often linked to obesity as a contributing factor. This study aimed to assess the potential protective effects of purslane extract in male albino rats with induced arthritis and obesity. Fifty rats were randomly assigned to five groups a control group, an induced arthritis-high-fat diet group, a high-dose purslane extract-supplemented group (300â¯mg/kg body weight) for 8 weeks, a low-dose purslane extract-supplemented group (150â¯mg/kg body weight) for 8 weeks, and a metformin-supplemented group. Arthritis was induced in the rats using Complete Freund's Adjuvant. Plasma biomarkers, including Total Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol, C Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Rheumatoid Factor (RF), and Anti-CCP, were assessed in each group. The results revealed a significant improvement in these biomarkers in the high-dose purslane-supplemented group (300â¯mg/kg body weight) compared to the induced arthritis-high-fat-diet group. This suggests a potential protective role of purslane against arthritis associated with obesity, likely attributed to its lipolytic capacity and anti-inflammatory properties. These findings contribute to our understanding of the interplay between obesity, arthritis, and natural interventions, providing valuable insights for future therapeutic approaches.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Experimental
/
Plant Extracts
/
Obesity
Limits:
Animals
Language:
En
Journal:
Prostaglandins Other Lipid Mediat
Journal subject:
ENDOCRINOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos