The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice.
Obesity (Silver Spring)
; 32(4): 733-742, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38410048
ABSTRACT
OBJECTIVE:
High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed hedonic overdrive, reverse causality, and passive overconsumption models.METHODS:
A total of 12 groups of 20 individually housed 12-week-old C57BL/6 male mice were exposed to 12 high-fat diets with varying fat content from 40% to 80% (by calories), protein content from 5% to 30%, and carbohydrate content from 8.4% to 40%. Body weight and food intake were monitored for 30 days after 7 days at baseline on a standard low-fat diet.RESULTS:
After exposure to the diets, energy intake increased first, and body weight followed later. Intake then declined. The peak energy intake was dependent on both dietary protein and carbohydrate, but not the dietary fat and energy density, whereas the rate of decrease in intake was only related to dietary protein. On high-fat diets, the weight of food intake declined, but despite this average reduction of 14.4 g in food intake, they consumed, on average, 357 kJ more energy than at baseline.CONCLUSIONS:
The hedonic overdrive model fit the data best. The other two models were not supported.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Carbohydrates
/
Diet, High-Fat
Limits:
Animals
Language:
En
Journal:
Obesity (Silver Spring)
Journal subject:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
China